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5-MTHF Calcium

Updated: Jan 11

What is 5-Methyltetrahydrofolate calcium (5-MTHF calcium)?

5-Methyltetrahydrofolate calcium (5-MTHF calcium) is the calcium salt form of 5-methyltetrahydrofolate, the active and naturally occurring form of folate in the body. This compound is used in supplements and fortified foods as a source of folate.

The calcium salt of 5-MTHF is more stable than the free form and is often used in supplements because it provides the benefits of folate without requiring additional metabolic steps for absorption or utilization by the body. It's a common alternative for individuals who may have difficulty metabolizing synthetic folic acid or other forms of folate due to genetic variations or other health reasons.

Health benefits of using 5-Methyltetrahydrofolate calcium

Improved Folate Absorption: Unlike folic acid, 5-MTHF calcium is a bioavailable form of folate that does not require enzymatic conversion in the body. This means it can be readily absorbed and utilized by individuals who may have issues converting folic acid to its active form due to genetic variations or certain health conditions.

Support for Methylation Processes: 5-MTHF is crucial for methylation, a biochemical process essential for DNA synthesis, repair, and regulation of gene expression. Adequate folate levels, especially in the form of 5-MTHF, are important for these processes.

Cardiovascular Health: Folate may contribute to cardiovascular health by supporting healthy homocysteine levels. Elevated homocysteine is associated with an increased risk of cardiovascular issues, and folate helps in its metabolism.

Possible Mental Health Support: Some research suggests a link between folate deficiency and conditions like depression and anxiety. Adequate levels of folate, especially the active form 5-MTHF, might play a role in mental health.


Individual responses and needs can vary, so it's essential to consult with a healthcare professional before starting any supplement regimen to determine the appropriate dosage and ensure its suitable for health needs.


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